TAM receptors in cardiovascular disease

L McShane, I Tabas, G Lemke… - Cardiovascular …, 2019 - academic.oup.com
The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl,
and MerTK. Since their discovery in the early 1990s, they have been studied for their ability …

Definition of left ventricular remodelling following ST-elevation myocardial infarction: a systematic review of cardiac magnetic resonance studies in the past decade

D Legallois, A Hodzic, J Alexandre, C Dolladille… - Heart Failure …, 2022 - Springer
An increase in left ventricular volumes between baseline and follow-up imaging is the main
criteria for the quantification of left ventricular remodelling (LVR) after ST-elevation …

Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction

M DeBerge, K Glinton, M Subramanian… - The Journal of …, 2021 - Am Soc Clin Investig
Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue
injury and as such have been proposed as therapeutic targets to promote inflammation …

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction

K Shirakawa, J Endo, M Kataoka… - Journal of the …, 2020 - Am Heart Assoc
Background We previously reported that osteopontin plays an essential role in accelerating
both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after …

Microvesicles in plasma reflect coronary flow reserve in patients with cardiovascular disease

P Bryl-Górecka, K James, K Torngren… - American Journal …, 2021 - journals.physiology.org
High levels of microvesicles (MVs), a type of extracellular vesicles, are detected in several
pathological conditions. We investigated the connection between coronary flow reserve …

Potential diagnostic and prognostic of efferocytosis-related unwanted soluble receptors/ligands as new non-invasive biomarkers in disorders: a review

A Tajbakhsh, SM Gheibihayat, RA Taheri… - Molecular Biology …, 2022 - Springer
Efferocytosis is the process by which apoptotic cells are removed without inflammation to
maintain tissue homeostasis, prevent unwanted inflammatory responses, and inhibit …

Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload

M Batlle, N Castillo, A Alcarraz, S Sarvari… - PLoS …, 2019 - journals.plos.org
Background AXL is a receptor tyrosine kinase that has been related to kidney and vascular
disorders. Heart failure patients with reduced ejection fraction have higher AXL in serum …

Electrochemical immunosensing of Growth arrest‐specific 6 in human plasma and tumor cell secretomes

C Muñoz‐San Martín, V Pérez‐Ginés… - Electrochemical …, 2022 - Wiley Online Library
Abstract Growth arrest‐specific 6 (GAS6) protein plays a key role in processes related to
proliferation, inflammation, angiogenesis, and atherosclerotic plaque formation. In addition …

Prognostic value of plasma sAXL in patients with heart failure: insights from the DRAGON‐HF trial

Y Liu, X Wang, X Pan, T Ma, Y Xu, Q Fen… - ESC Heart …, 2023 - Wiley Online Library
Background Little is known about the predictive value of soluble AXL (sAXL) in heart failure
(HF). This study aimed to describe the prognostic value of plasma sAXL in patients with …

Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: a prospective cohort study

X Zhang, H Hong, X Wang, Q Xie, L Miao, L Zhang - Clinica Chimica Acta, 2022 - Elsevier
Background Growth-arrest-specific protein 6 (Gas6) exerts nervous protective effects on
acute brain injury. We endeavored to ascertain whether serum Gas6 concentrations are …