The abnormal expression and function of myelin‐related proteins contribute to nervous
system dysfunction associated with neuropsychiatric disorders; however, the underlying …

Rapid nerve conduction in jawed vertebrates is facilitated by the myelination of axons, which
evolved in ancient cartilaginous fish. We aim to understand the coevolution of myelin and …

The membrane-anchored myelin enzyme 2′, 3′-cyclic nucleotide 3′-phosphodiesterase
(CNPase) was discovered in the early 1960s and has since then troubled scientists with its …

White matter (WM) plasticity during adulthood is a recently described phenomenon by which
experience can shape brain structure. It has been observed in humans using diffusion …

Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in
peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane …

Molecular characterization of myelin is a prerequisite for understanding the normal structure
of the axon/myelin-unit in the healthy nervous system and abnormalities in myelin-related …

Deficiency of the major constituent of central nervous system (CNS) myelin, proteolipid
protein (PLP), causes axonal pathology in spastic paraplegia type‐2 patients and in Plp1null …

Proteolipid protein (PLP) is the most abundant integral membrane protein in compact central
nervous system myelin, and null mutations of the PLP1 gene cause spastic paraplegia type …

Repetitive mild traumatic brain injury (r-mTBI) results in neuropathological and biochemical
consequences in the human visual system. Using a recently developed mouse model of r …

Myelin ensheathes selected axonal segments within the nervous system, resulting primarily
in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the …