Proteome profile of myelin in the zebrafish brain

SB Siems, O Jahn, LJ Hoodless, RB Jung… - Frontiers in cell and …, 2021 - frontiersin.org
The velocity of nerve conduction along vertebrate axons depends on their ensheathment
with myelin. Myelin membranes comprise specialized proteins well characterized in mice …

Structural and functional evolution of 2′, 3′-cyclic nucleotide 3′-phosphodiesterase

M Myllykoski, L Seidel, G Muruganandam, A Raasakka… - Brain research, 2016 - Elsevier
Abstract 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is an abundant
membrane-associated enzyme within the vertebrate myelin sheath. While the physiological …

Proteomic profiling in the brain of CLN1 disease model reveals affected functional modules

S Tikka, E Monogioudi, A Gotsopoulos… - Neuromolecular …, 2016 - Springer
Neuronal ceroid lipofuscinoses (NCL) are the most commonly inherited progressive
encephalopathies of childhood. Pathologically, they are characterized by endolysosomal …

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo

J Logue, VM Melville, J Ardanuy, MB Frieman - PLoS pathogens, 2023 - journals.plos.org
The COVID-19 pandemic has claimed over 6.5 million lives worldwide and continues to
have lasting impacts on the world's healthcare and economic systems. Several approved …

Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking

J Patzig, K Kusch, R Fledrich, MA Eichel, KA Lüders… - Glia, 2016 - Wiley Online Library
Protein zero (P0) is the major structural component of peripheral myelin. Lack of this
adhesion protein from Schwann cells causes a severe dysmyelinating neuropathy with …

Investigating brain connectivity heritability in a twin study using diffusion imaging data

KK Shen, S Rose, J Fripp, KL McMahon… - NeuroImage, 2014 - Elsevier
Heritability of brain anatomical connectivity has been studied with diffusion-weighted
imaging (DWI) mainly by modeling each voxel's diffusion pattern as a tensor (eg, to compute …

Proteomics‐level analysis of myelin formation and regeneration in a mouse model for vanishing white matter disease

I Gat‐Viks, T Geiger, M Barbi, G Raini… - Journal of …, 2015 - Wiley Online Library
Vanishing white matter (VWM) is a recessive neurodegenerative disease caused by
mutations in translation initiation factor eIF 2B and leading to progressive brain myelin …

Determinants of ligand binding and catalytic activity in the myelin enzyme 2′, 3′-cyclic nucleotide 3′-phosphodiesterase

A Raasakka, M Myllykoski, S Laulumaa, M Lehtimäki… - Scientific Reports, 2015 - nature.com
Abstract 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is an enzyme highly
abundant in the central nervous system myelin of terrestrial vertebrates. The catalytic …

Biomedical applications of ion mobility-enhanced data-independent acquisition-based label-free quantitative proteomics

U Distler, J Kuharev, S Tenzer - Expert review of proteomics, 2014 - Taylor & Francis
Mass spectrometry-based proteomics greatly benefited from recent improvements in
instrument performance and the development of bioinformatics solutions facilitating the high …

Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35

R Hardt, S Jordans, D Winter… - Human Molecular …, 2020 - academic.oup.com
Abstract Spastic paraplegia 35 (SPG35)(OMIM: 612319) or fatty acid hydroxylase-
associated neurodegeneration (FAHN) is caused by deficiency of fatty acid 2-hydroxylase …