Translocations involving band 12p13 are one of the most commonly observed chromosomal
abnormalities in human leukemia and myelodysplastic syndrome. Their frequently result in …

Background The present study was designed to test the hypothesis that inactivation of
virtually any component within the pathway containing the BRCA1 and BRCA2 proteins …

Translocations in hematologic disease of myeloid or lymphoid origin with breakpoints at
chromosome band 12p13 frequently result in rearrangements of the Ets variant gene 6 …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …

The TEL gene, which is frequently rearranged in human leukemias of both myeloid and
lymphoid origin, encodes a member of the Ets family of transcription factors. The TEL gene is …

Genomics, particularly high‐throughput sequencing and characterization of expressed
human genes, has created new opportunities for drug discovery. Knowledge of all the …

Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …

The TEL gene on 12p12-13 is a target for a number of translocations associated with various
hematological malignancies. The fusion of the TEL gene to the Syk gene in a patient with …

We report the fusion of the Huntingtin interactin protein 1 (HIP1) gene to the platelet-derived
growth factor βreceptor (PDGFβR) gene in a patient with chronic myelomonocytic leukemia …

Leukemia is an acquired genetic disease caused by the accumulation of chromosomal
abnormalities which modify either the biochemical property or the level of expression of …