Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Senescent cells have undergone permanent growth arrest, adopt an altered secretory
phenotype, and accumulate in the kidney and other organs with ageing and injury …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …

Acute kidney injury (AKI) is strongly associated with mortality, independently of its cause.
The kidney contributes to up to 40% of systemic glucose production by gluconeogenesis …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Acute kidney injury (AKI) and chronic kidney diseases are associated with high mortality and
morbidity. Although the underlying mechanisms determining the transition from acute to …