Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

W Zhao, Y Cong, HM Li, S Li, Y Shen, Q Qi… - Natural Product …, 2021 - pubs.rsc.org
Covering: up to 2020 As a main bioactive component of the Chinese, Indian, and American
Podophyllum species, the herbal medicine, podophyllotoxin (PTOX) exhibits broad spectrum …

Worked to the bone: antibody-based conditioning as the future of transplant biology

JM Griffin, FM Healy, LN Dahal, Y Floisand… - Journal of Hematology & …, 2022 - Springer
Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in
eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding …

Phase III randomized study of rituximab/carmustine, etoposide, cytarabine, and melphalan (BEAM) compared with iodine-131 tositumomab/BEAM with autologous …

JM Vose, S Carter, LJ Burns, E Ayala… - Journal of Clinical …, 2013 - ascopubs.org
Purpose This clinical trial evaluated standard-dose radioimmunotherapy with a
chemotherapy-based transplantation regimen followed by autologous hematopoietic cell …

A novel CAR expressing NK cell targeting CD25 with the prospect of overcoming immune escape mechanism in cancers

M Dehbashi, Z Hojati, M Motovali-Bashi… - Frontiers in …, 2021 - frontiersin.org
For many years, high-affinity subunit of IL-2 receptor (CD25) has been considered as a
promising therapeutic target for different pathologic conditions like allograft rejection …

Anti-CD25 radioimmunotherapy with BEAM autologous hematopoietic cell transplantation conditioning in Hodgkin lymphoma

AF Herrera, J Palmer, V Adhikarla, D Yamauchi… - Blood …, 2021 - ashpublications.org
High-risk relapsed or refractory (R/R) classical Hodgkin lymphoma (HL) is associated with
poor outcomes after conventional salvage therapy and autologous hematopoietic cell …

Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia‑1

HJ Yu, J Shin, SJ Choi, SD Cho - … Journal of Molecular …, 2023 - spandidos-publications.com
Podophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked
cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying …

Cysteine-specific 89Zr-labeled anti-CD25 IgG allows immuno-PET imaging of interleukin-2 receptor-α on T cell lymphomas

JH Lee, KH Jung, M Kim, KH Lee - Frontiers in Immunology, 2022 - frontiersin.org
Introduction Positron emission tomography (PET) using radiolabeled Abs as imaging tracer
is called immuno-PET. Immuno-PET can verify therapeutic Ab delivery and can …

Yttrium-90 Anti-CD25-BEAM-Conditioning for Autologous Hematopoietic Cell Transplantation in Peripheral T Cell Lymphoma

J Zain, NC Tsai, JM Palmer, JR Simpson… - Blood …, 2024 - ashpublications.org
Peripheral T cell lymphomas (PTCL) have a poor prognosis with current treatments. High-
dose chemotherapy followed by autologous hematopoietic cell transplant (AHCT) is used as …

Radionuclide therapy of lymphomas

AS Parihar, HA Jacene, SH Tirumani… - Nuclear Oncology: from …, 2022 - Springer
Radioimmunotherapy (RIT) is an effective therapy for non-Hodgkin lymphoma (NHL) in a
variety of settings and is well tolerated. Current studies continue to investigate the role of RIT …

Podophyllotoxin enfeebles human oral squamous cell carcinoma through Myeloid cell leukemia-1

HJ Yu, JA Shin, SJ Choi, SD Cho - 2023 - researchsquare.com
Background Podophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits
marked cytotoxic effects against cancer cells; however, the specific molecular mechanism …