One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Mitochondria are known to be functional organelles, but their role as a signaling unit is
increasingly being appreciated. The identification of a short open reading frame (sORF) in …

The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic
activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory …

Improvements in healthcare and nutrition have generated remarkable increases in life
expectancy worldwide. This is one of the greatest achievements of the modern world yet it …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Metformin, a first-line diabetes drug linked to cancer prevention in retrospective clinical
analyses, inhibits cellular transformation and selectively kills breast cancer stem cells …

Folate-mediated one carbon (1C) metabolism supports a series of processes that are
essential for the cell. Through a number of interlinked reactions happening in the cytosol …

Mitochondria are ancient organelles that are thought to have emerged from once free-living
α-proto-bacteria. As such, they still possess several bacterial-like qualities, including a semi …

Metformin is widely prescribed for the treatment of type II diabetes. Recently, it has been
proposed that this compound or related biguanides may have antineoplastic activity …