There is substantial epidemiological evidence pointing to an increased incidence of breast
cancer and morbidity in obese, prediabetic, and diabetic patients. In vitro studies strongly …

There is a global and urgent need for expanding our current therapeutical arsenal against
leukemia in order to improve their actual cure rates and fight relapse. Targeting the …

Malignant tumors are a major cause of death, and their incidence is increasing worldwide.
Although the survival rate for some cancers has improved, treatments for other malignant …

Simple Summary The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2),
which converts serine into glycine and generates 1C units for cell growth, is one of the most …

Antibody responses to vaccinations or infections decline upon aging. In this study we tested
if metabolic changes in B cells may contribute to attenuation of responses to influenza …

We show here that the antidiabetic agents metformin and phenformin and the AMPK
activator AICAR exert strong anti-tumoural effects on tPTEN−/− lymphoma cells and on …

Introduction Despite the ability of cancer cells to survive glucose deprivation, most studies
on anti-cancer effect of metformin explored its impact on glucose metabolism. No study ever …

The main anti-diabetic effect of metformin mediated through stimulation of adenosine
monophosphate (AMP)-activated protein kinase (AMPK) is the inhibition of hepatic …

Background Diabetes has been associated with increased risk of cancer, including breast
cancer and colorectal cancer. Metformin, an oral hypoglycemic drug, but not other anti …

Therapeutic interventions based on metabolic inhibitor-based therapies are expected to be
less prone to acquired resistance. However, there has not been any study assessing the …