The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …

The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …

The human genome project and its search for factors underlying human diseases has
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …