Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by
pancreatic islet inflammation (insulitis) and specific pancreatic β-cell destruction by an …

Aims/hypothesis Islet vascular fibrosis may play an important role in the progression of type
2 diabetes, but there are no mouse models allowing detailed mechanistic studies to …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

Objective Type 1 diabetes is characterized by autoimmune destruction of β-cells leading to
severe insulin deficiency. Although many improvements have been made in recent years …

In the pathogenesis of diabetes mellitus (DM), islet microvasculares are severely damaged
due to glucolipotoxicity and other reasons. Vascular endothelial growth factor (VEGF) is an …

A better understanding of processes controlling the development and function of pancreatic
islets is critical for diabetes prevention and treatment. Here, we reveal a previously …

Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

Traumatic brain injury (TBI) disrupts the blood–brain barrier (BBB) and reduces cerebral
glucose uptake. Vascular endothelial growth factor (VEGF) is believed to play a key role in …

The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in
haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and …

Pancreatic islets are the body's central rheostat that regulates glucose homeostasis through
the production of different hormones, including β cell-derived insulin. During obesity …