Children exposed to a maternal Western-style diet in utero have an increased risk of
developing type 2 diabetes. Understanding the mechanisms and an investigation of …

Intercellular junctions play a role in regulating islet cytoarchitecture, insulin biosynthesis and
secretion. In this study, we investigated the animal metabolic state as well as islet histology …

RNA binding protein HuD plays essential roles in gene expression by regulating RNA
metabolism, and its dysregulation is involved in the pathogenesis of several diseases …

Islet inflammation is associated with defective β cell function and mass in type 2 diabetes
(T2D). Glycogen Synthase Kinase 3β (GSK3β) has been identified as an important regulator …

Type 2 diabetes (T2D) is evolving into a global disease and patients have a systemic low-
grade inflammation, yet the role of this inflammation is still not established. One plausible …

Aims Sodium‐glucose co‐transporter 2 inhibitors, including dapagliflozin, improve ß cell
function in type 2 diabetic individuals. Whether dapagliflozin can protect islet microvascular …

Revascularization of the islet transplant is a crucial step that defines the success rate of
patient recovery. Bone marrow-derived mesenchymal stem cells (BMSCs) have been …

Hydroxychloroquine (HCQ) has been demonstrated to reduce the risk to develop diabetes
mellitus (DM). However no previous experimental study had investigated its effect on the …

The receptor tyrosine kinase c-Kit plays an integral role in maintaining β-cell mass and
function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its …

The dysregulation of receptor tyrosine kinases (RTKs) in multiple cell types during chronic
inflammation is indicative of their pathogenic role in autoimmune diseases. Among the many …