Deficient vascularization is a major driver of early islet graft loss and one of the primary
reasons for the failure of islet transplantation as a viable treatment for type 1 diabetes. This …

Insulin is an essential regulator of blood glucose homeostasis that is produced exclusively
by β cells within the pancreatic islets of healthy individuals. In those affected by diabetes …

The dysregulation of receptor tyrosine kinases (RTKs) in multiple cell types during chronic
inflammation is indicative of their pathogenic role in autoimmune diseases. Among the many …

The receptor tyrosine kinase c-Kit plays an integral role in maintaining β-cell mass and
function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its …

Pancreatic islet transplantation is a promising therapy to regain glycemic control in diabetic
patients. The selection of ideal grafts is the basis to guarantee short‐term effectivity and …

The aim of this study was to evaluate the effects of angiotensin‐converting enzyme 2 (ACE2)
on glucose homeostasis and islet function in mice. Male wildtype (WT) and ACE2 knockout …

Aims Changes in the islet vasculature have been implicated in the regulation of β-cell
survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to …

Vascular endothelial growth factor (VEFG) is a major angiogenic factor involved in both
normal physiological processes, such as embryonic development and wound healing, and …

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of
developing abnormal glucose metabolism and type-2 diabetes during childhood …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …