[HTML][HTML] The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease

S Ma, J Zhang, H Liu, S Li, Q Wang - Frontiers in cell and …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a
refractory disease with many immune abnormalities and pathologies in the gastrointestinal …

[HTML][HTML] Macrophage polarization: an important candidate regulator for lung diseases

L Deng, Z Jian, T Xu, F Li, H Deng, Y Zhou, S Lai, Z Xu… - Molecules, 2023 - mdpi.com
Macrophages are crucial components of the immune system and play a critical role in the
initial defense against pathogens. They are highly heterogeneous and plastic and can be …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

Genistein-derived ROS-responsive nanoparticles relieve colitis by regulating mucosal homeostasis

W Fan, S Zhang, Y Wu, T Lu, J Liu, X Cao… - … Applied Materials & …, 2021 - ACS Publications
Disruption of intestinal homeostasis is an important event in the development of
inflammatory bowel disease (IBD), and genistein (GEN) is a candidate medicine to prevent …

[HTML][HTML] Joint together: The etiology and pathogenesis of ankylosing spondylitis

Y Xiong, M Cai, Y Xu, P Dong, H Chen, W He… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines.
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …

[HTML][HTML] A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

K Wang, T Mao, X Lu, M Wang, Y Yun, Z Jia… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and
incurable symptoms, causes immense suffering and economic burden for patients due to the …

[HTML][HTML] Astragaloside IV alleviates the experimental DSS-induced colitis by remodeling macrophage polarization through STAT signaling

L Tian, JL Zhao, JQ Kang, S Guo, N Zhang… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal
inflammation, which currently lacks safe and effective medicine. Some previous studies …

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Y Liu, J Huang, S Li, Z Li, C Chen, G Qu, K Chen… - Biomaterials …, 2024 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals
worldwide. However, current drug therapies for IBD are plagued by significant side effects …

[HTML][HTML] Resveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis

X Xu, DKW Ocansey, B Pei, Y Zhang, N Wang… - European Journal of …, 2023 - Springer
Background Inflammatory bowel disease (IBD) is a global disease with a growing public
health concern and is associated with a complex interplay of factors, including the …

[HTML][HTML] Mitochondrial DNA copy number is associated with Crohn's disease: a comprehensive Mendelian randomization analysis

X Cai, X Li, C Liang, M Zhang, Y Xu, Z Dong, Y Weng… - Scientific reports, 2023 - nature.com
Mitochondrial DNA plays a critical role in the pathophysiological process of inflammation.
However, the relationship between mitochondrial DNA copy number (mtDNA-CN) and …