[HTML][HTML] The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention
AKS Jayalatha, L Hesse, ME Ketelaar… - Pharmacology & …, 2021 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
IL‐33: biological properties, functions, and roles in airway disease
LY Drake, H Kita - Immunological reviews, 2017 - Wiley Online Library
Summary Interleukin (IL)‐33 is a key cytokine involved in type 2 immunity and allergic
airway diseases. Abundantly expressed in lung epithelial cells, IL‐33 plays critical roles in …
airway diseases. Abundantly expressed in lung epithelial cells, IL‐33 plays critical roles in …
The potential of biologics for the treatment of asthma
G Pelaia, A Vatrella, R Maselli - Nature reviews Drug discovery, 2012 - nature.com
Recent advances in the knowledge of asthma pathobiology suggest that biological therapies
that target cytokines can be potentially useful for the treatment of this complex and …
that target cytokines can be potentially useful for the treatment of this complex and …
[HTML][HTML] Inducible bronchus-associated lymphoid tissue: taming inflammation in the lung
JY Hwang, TD Randall, A Silva-Sanchez - Frontiers in immunology, 2016 - frontiersin.org
Following pulmonary inflammation, leukocytes that infiltrate the lung often assemble into
structures known as inducible Bronchus-Associated Lymphoid Tissue (iBALT). Like …
structures known as inducible Bronchus-Associated Lymphoid Tissue (iBALT). Like …
[HTML][HTML] The IL-1 cytokine family as custodians of barrier immunity
Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …
functioning of innate and adaptive immunity and the genesis of inflammation. They are …
Diagnosis and management of eosinophilic asthma: a US perspective
HH Walford, TA Doherty - Journal of asthma and allergy, 2014 - Taylor & Francis
Eosinophilic asthma is now recognized as an important subphenotype of asthma based on
the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be …
the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be …
Refractory asthma: mechanisms, targets, and therapy
JL Trevor, JS Deshane - Allergy, 2014 - Wiley Online Library
Asthma is a common medical condition affecting 300 million people worldwide. Airway
inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous …
inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous …
[HTML][HTML] Cytokines stimulated by IL-33 in human skin mast cells: Involvement of NF-κB and p38 at distinct levels and potent co-operation with FcεRI and MRGPRX2
K Franke, Z Wang, T Zuberbier, M Babina - International Journal of …, 2021 - mdpi.com
The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by
what mechanisms it elicits cytokines in MCs from human skin remains poorly understood …
what mechanisms it elicits cytokines in MCs from human skin remains poorly understood …
Interleukin‐33 in allergy
Abstract Interleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1
and IL‐18, and is considered to be important for host defense against nematodes by …
and IL‐18, and is considered to be important for host defense against nematodes by …
[HTML][HTML] Interleukin-33: its emerging role in allergic diseases
W Ding, GL Zou, W Zhang, XN Lai, HW Chen, LX Xiong - Molecules, 2018 - mdpi.com
Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS),
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …