Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal
models of diabetes represent an important tool in diabetes investigation that helps us to …

Diabetes mellitus affects almost half a billion patients worldwide and results from either
destruction of β‐cells responsible for insulin secretion or increased tissue resistance to …

Bile acids are synthesized from cholesterol in the liver, excreted with bile into the duodenum,
almost completely taken up again in the distal ileum and finally returned to the liver with …

Bile acids are endogenous emulsifiers synthesized from cholesterol having a peculiar
amphiphilic structure. Appreciation of their beneficial effects on human health, recognized …

The antilipidemic drug, probucol (PB), has demonstrated potential applications in Type 2
diabetes (T2D) through its protective effects on pancreatic β-cells. PB has poor solubility and …

Introduction In previous studies carried out in our laboratory, a bile acid (BA) formulation
exerted a hypoglycaemic effect in a rat model of type-1 diabetes (T1D). When the …

There have not been yet enough studies about effects of beta glucan and gliclazide on
oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The …

The aim of this study was to develop a drug-specific absorption model for gliclazide (GLK)
using mechanistic gastrointestinal simulation technology (GIST) implemented in GastroPlus …

Probucol (PB) is an hypolipidaemic drug with potential antidiabetic effects. We showed
recently using in vitro studies that when PB was incorporated with stabilising lipophilic bile …

Major problem for diabetic patients represents damage of blood vessels and the oxidative
stress of the brain cells due to increased concentration of free radicals and poor nutrition of …