The intracellular environmental is a hostile one. Free radicals and related oxygen and
nitrogen-based oxidizing agents persistently pulverize and damage molecules in the vicinity …

Peroxynitrite (ONOO−) is an endogenous molecule, formed by rapid coupling between NO
and O2−. ONOO− is known to be a strong oxidant of thiols and metalloorganic compounds …

Melatonin has a number of properties as a consequence of which it could be beneficial to
animals as they age. Of particular interest are its ubiquitous actions as a direct and indirect …

The tropical parasite Schistosoma mansoni causes granulomatous inflammation after its
eggs lodge in hepatic portal capillaries. In vitro studies indicate that the host's response …

Mitochondria play a central role in cellular physiology. Besides their classic function of
energy metabolism, mitochondria are involved in multiple cell functions, including energy …

The perception of pain is altered by inflammatory processes. Anti‐inflammatory drugs block
this by raising the pain threshold and by reducing the inflammatory process. Melatonin is …

The reactions of cyclic 3-hydroxymelatonin (3-OHM) with hydroxyl (˙ OH) and hydroperoxyl (˙
OOH) radicals were studied using Density Functional Theory. Two environments, mimicking …

Melatonin is produced and released by the pineal gland in a circadian rhythm. This
neurohormone has proven to be an antioxidant and anti-inflammatory molecule able to …

Considerable evidence shows that oxidative stress exists in the pathophysiological process
of female reproductive system diseases. At present, there have been many studies on …

Modulation of catalase activity can be one of the probable adaptive mechanisms in plants to
alleviate stress by regulating intracellular hydrogen peroxide (H2O2) levels. Catalase is …