Reactive oxygen species and lipid peroxidation play a role in the pathogenesis induced by
the non-steroidal anti-inflammatory drug indomethacin. Melatonin (MLT) protection against …

This article discusses data showing that mammals, including humans, have two sources of
melatonin that exhibit different functions. The best-known source of melatonin, herein …

In the presence of hydrogen peroxide, horseradish peroxidase (HRP) catalyzes the
production of N1-acetyl-N2-formyl-5-methoxykynuramine from melatonin. This reaction …

Since biological membranes are composed of lipids and proteins we tested the in vitro
antioxidant properties of several indoleamines from the tryptophan metabolic pathway in the …

We have reexamined claims that melatonin directly scavenges hydrogen peroxide and
shown them to be unfounded. Relative hydrogen peroxide concentrations were determined …

Melatonin treatment showed a potent neuroprotective action in experimental models and in
clinical studies. However, the entire disease prevention is not observed with melatonin …

At present, there are no FDA-approved pharmacological therapies for acute treatment of
traumatic brain injury (TBI) patients that are conclusively proven to mitigate the often …

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism
and the health of humans. Available as a dietary supplement in the United States since …

The basal levels of expression of mRNA of cytokines, interleukin-6 (IL-6) and tumor necrosis
factor (TNF-α), in the cerebral cortex of 5 and 26 month-old male B6C3F1 mice have been …

Melatonin's functions exceed by far the role of a hormone that mediates the signal darkness.
In extrapineal tissues, it is produced in considerably higher quantities than in the pineal …