[HTML][HTML] Molecular mechanisms involving the sonic hedgehog pathway in lung cancer therapy: recent advances

C Ma, K Hu, I Ullah, QK Zheng, N Zhang… - Frontiers in …, 2022 - frontiersin.org
According to the latest statistics from the International Agency for Research on Cancer
(IARC), lung cancer is one of the most lethal malignancies in the world, accounting for …

Drug repurposing: An emerging strategy in alleviating skin cancer

P Kumbhar, K Kole, T Yadav, A Bhavar… - European Journal of …, 2022 - Elsevier
Skin cancer is one of the most common forms of cancer. Several million people are
estimated to have affected with this condition worldwide. Skin cancer generally includes …

First-line gemcitabine, nab-paclitaxel, and oxaliplatin chemotherapy with itraconazole in patients with metastatic pancreatic cancer: a single institution experience

M Sawasaki, H Tsubamoto, A Sugihara… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Combination chemotherapy with gemcitabine, nab-paclitaxel, oxaliplatin,
and itraconazole (GnPO-ITC) was administered as first-line chemotherapy in patients with …

[HTML][HTML] Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

RE Kast, A Alfieri, HI Assi, TC Burns, AM Elyamany… - Cancers, 2022 - mdpi.com
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

[HTML][HTML] Terconazole, an azole antifungal drug, increases cytotoxicity in antimitotic drug-treated resistant cancer cells with substrate-specific P-gp inhibitory activity

JS Lee, Y Oh, JH Park, SY Kyung, HS Kim… - International Journal of …, 2022 - mdpi.com
Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …

[HTML][HTML] Investigation of the Antifungal and Anticancer Effects of the Novel Synthesized Thiazolidinedione by Ion-Conductance Microscopy

N Savin, A Erofeev, R Timoshenko, A Vaneev… - Cells, 2023 - mdpi.com
In connection with the emergence of new pathogenic strains of Candida, the search for more
effective antifungal drugs becomes a challenge. Part of the preclinical trials of such drugs …

[HTML][HTML] Induced cell cycle arrest in triple-negative breast cancer by combined treatment of itraconazole and rapamycin

HT Wu, CL Li, ZX Fang, WJ Chen, WT Lin… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is the aggressive molecular type of breast carcinoma,
with a high metastasis/relapse incidence and cancer-related death rate, due to lack of …

[HTML][HTML] Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention

BT Baby, AM Kulkarni, PKR Gayam… - Archives of Biochemistry …, 2024 - Elsevier
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several
physiological processes, such as wound healing and organ homeostasis. In a pathological …

Itraconazole inhibits tumor growth via CEBPB‐mediated glycolysis in colorectal cancer

Y Zhang, L Li, F Chu, H Wu, X Xiao, J Ye… - Cancer Science, 2024 - Wiley Online Library
Advanced colorectal cancer (CRC) is characterized by a high recurrence and metastasis
rate, which is the primary cause of patient mortality. Unfortunately, effective anti‐cancer …

Non-small Cell Lung Cancer Treatment: Current Status of Drug Repurposing and Nanoparticle-based Drug Delivery Systems

TG INCI, S ACAR, D BALIK - Turkish Journal of Biology, 2024 - journals.tubitak.gov.tr
Drug repurposing is the strategy of drug utilization for a treatment option other than the
intended indications and has increased over the past decades, especially within cancer …