[HTML][HTML] Molecular mechanisms involving the sonic hedgehog pathway in lung cancer therapy: recent advances
C Ma, K Hu, I Ullah, QK Zheng, N Zhang… - Frontiers in …, 2022 - frontiersin.org
According to the latest statistics from the International Agency for Research on Cancer
(IARC), lung cancer is one of the most lethal malignancies in the world, accounting for …
(IARC), lung cancer is one of the most lethal malignancies in the world, accounting for …
Drug repurposing: An emerging strategy in alleviating skin cancer
P Kumbhar, K Kole, T Yadav, A Bhavar… - European Journal of …, 2022 - Elsevier
Skin cancer is one of the most common forms of cancer. Several million people are
estimated to have affected with this condition worldwide. Skin cancer generally includes …
estimated to have affected with this condition worldwide. Skin cancer generally includes …
First-line gemcitabine, nab-paclitaxel, and oxaliplatin chemotherapy with itraconazole in patients with metastatic pancreatic cancer: a single institution experience
M Sawasaki, H Tsubamoto, A Sugihara… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Combination chemotherapy with gemcitabine, nab-paclitaxel, oxaliplatin,
and itraconazole (GnPO-ITC) was administered as first-line chemotherapy in patients with …
and itraconazole (GnPO-ITC) was administered as first-line chemotherapy in patients with …
[HTML][HTML] Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …
a more effective treatment than we currently have. To do this we outline why a regimen …
[HTML][HTML] Terconazole, an azole antifungal drug, increases cytotoxicity in antimitotic drug-treated resistant cancer cells with substrate-specific P-gp inhibitory activity
JS Lee, Y Oh, JH Park, SY Kyung, HS Kim… - International Journal of …, 2022 - mdpi.com
Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
[HTML][HTML] Investigation of the Antifungal and Anticancer Effects of the Novel Synthesized Thiazolidinedione by Ion-Conductance Microscopy
N Savin, A Erofeev, R Timoshenko, A Vaneev… - Cells, 2023 - mdpi.com
In connection with the emergence of new pathogenic strains of Candida, the search for more
effective antifungal drugs becomes a challenge. Part of the preclinical trials of such drugs …
effective antifungal drugs becomes a challenge. Part of the preclinical trials of such drugs …
[HTML][HTML] Induced cell cycle arrest in triple-negative breast cancer by combined treatment of itraconazole and rapamycin
HT Wu, CL Li, ZX Fang, WJ Chen, WT Lin… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is the aggressive molecular type of breast carcinoma,
with a high metastasis/relapse incidence and cancer-related death rate, due to lack of …
with a high metastasis/relapse incidence and cancer-related death rate, due to lack of …
[HTML][HTML] Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention
BT Baby, AM Kulkarni, PKR Gayam… - Archives of Biochemistry …, 2024 - Elsevier
Hedgehog (Hh) signaling plays a significant role in embryogenesis and several
physiological processes, such as wound healing and organ homeostasis. In a pathological …
physiological processes, such as wound healing and organ homeostasis. In a pathological …
Itraconazole inhibits tumor growth via CEBPB‐mediated glycolysis in colorectal cancer
Y Zhang, L Li, F Chu, H Wu, X Xiao, J Ye… - Cancer Science, 2024 - Wiley Online Library
Advanced colorectal cancer (CRC) is characterized by a high recurrence and metastasis
rate, which is the primary cause of patient mortality. Unfortunately, effective anti‐cancer …
rate, which is the primary cause of patient mortality. Unfortunately, effective anti‐cancer …
Non-small Cell Lung Cancer Treatment: Current Status of Drug Repurposing and Nanoparticle-based Drug Delivery Systems
Drug repurposing is the strategy of drug utilization for a treatment option other than the
intended indications and has increased over the past decades, especially within cancer …
intended indications and has increased over the past decades, especially within cancer …