[HTML][HTML] The T cell immune response against SARS-CoV-2
P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …
Single-cell proteomics enabled by next-generation sequencing or mass spectrometry
In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …
single cells has greatly advanced our understanding of the underlying heterogeneity of …
[HTML][HTML] Distinguishing features of Long COVID identified through immune profiling
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …
CoV-2 can result in the development of a post-acute infection syndrome known as long …
[HTML][HTML] Dictionary learning for integrative, multimodal and scalable single-cell analysis
Mapping single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
[PDF][PDF] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
[HTML][HTML] Dysregulation of brain and choroid plexus cell types in severe COVID-19
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …
[PDF][PDF] The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …
[PDF][PDF] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
[HTML][HTML] Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or …
EW Ely, AV Ramanan, CE Kartman… - The Lancet …, 2022 - thelancet.com
Summary Background The oral, selective Janus kinase 1/2 inhibitor baricitinib has shown
efficacy in studies of hospitalised adults with COVID-19. COV-BARRIER (NCT04421027) …
efficacy in studies of hospitalised adults with COVID-19. COV-BARRIER (NCT04421027) …
[HTML][HTML] CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
EM Bange, NA Han, P Wileyto, JY Kim, S Gouma… - Nature medicine, 2021 - nature.com
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the
immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …
immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …