Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
N Xiao, M Nie, H Pang, B Wang, J Hu, X Meng… - Nature …, 2021 - nature.com
Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal
outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can …
outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can …
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
Persistent serum protein signatures define an inflammatory subcategory of long COVID
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The …
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The …
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
F Karagiannis, K Peukert, L Surace, M Michla… - Nature, 2022 - nature.com
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate …
Advances and utility of the human plasma proteome
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
AC Aschenbrenner, M Mouktaroudi, B Krämer… - Genome medicine, 2021 - Springer
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …
variation to disease severity and outcome over time, we longitudinally assessed circulating …
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
Single-cell immunology of SARS-CoV-2 infection
Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …
with protective or pathological immunity against severe acute respiratory syndrome …