[HTML][HTML] Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
S Weingarten-Gabbay, S Klaeger, S Sarkizova… - Cell, 2021 - cell.com
T cell-mediated immunity plays an important role in controlling SARS-CoV-2 infection, but
the repertoire of naturally processed and presented viral epitopes on class I human …
the repertoire of naturally processed and presented viral epitopes on class I human …
[HTML][HTML] Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …
COVID-19. However, the immune signatures associated with immunopathology are poorly …
[HTML][HTML] COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly
variable disease severity and a bimodal course characterized by acute respiratory viral …
variable disease severity and a bimodal course characterized by acute respiratory viral …
[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …
instigating devastating effects on the global health care system whose impacts could be …
[HTML][HTML] Metabolic programs tailor T cell immunity in viral infection, cancer, and aging
SH Møller, PC Hsueh, YR Yu, L Zhang, PC Ho - Cell metabolism, 2022 - cell.com
Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …
[HTML][HTML] Translational precision medicine: an industry perspective
In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …
discovery and development face unprecedented opportunities for product and business …
[HTML][HTML] The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19
Summary Coronavirus disease 2019 (COVID-19) currently has few effective treatments.
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
[HTML][HTML] Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study
SK Byeon, AK Madugundu, K Garapati… - The Lancet Digital …, 2022 - thelancet.com
Background COVID-19 is a multi-system disorder with high variability in clinical outcomes
among patients who are admitted to hospital. Although some cytokines such as interleukin …
among patients who are admitted to hospital. Although some cytokines such as interleukin …
[HTML][HTML] Lessons learned: new insights on the role of cytokines in COVID-19
M Buszko, A Nita-Lazar, JH Park, PL Schwartzberg… - Nature …, 2021 - nature.com
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …
[HTML][HTML] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …