Contribution of brown adipose tissue to human energy metabolism

R Fernández-Verdejo, KL Marlatt, E Ravussin… - Molecular aspects of …, 2019 - Elsevier
The present “obesogenic'environment has favored excessive energy intake resulting in the
current obesity epidemic and its associated diseases. The epidemic has incentivized …

Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2023 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treating obesity and metabolic diseases. Beyond …

[HTML][HTML] Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

S Søberg, J Löfgren, FE Philipsen, M Jensen… - Cell Reports …, 2021 - cell.com
The Scandinavian winter-swimming culture combines brief dips in cold water with hot sauna
sessions, with conceivable effects on body temperature. We study thermogenic brown …

[HTML][HTML] Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue

ME Straat, CA Hoekx, FHP van Velden… - Cell Reports …, 2023 - cell.com
While brown adipose tissue (BAT) is activated by the beta-3-adrenergic receptor (ADRB3) in
rodents, in human brown adipocytes, the ADRB2 is dominantly present and responsible for …

Role of human brown fat in obesity, metabolism and cardiovascular disease: strategies to turn up the heat

JR Ruiz, B Martinez-Tellez, G Sanchez-Delgado… - Progress in …, 2018 - Elsevier
Human brown adipose tissue (BAT) was re-discovered in 2009 by several independent
groups, who showed that it is present and active in adults, as judged from the profound …

Omega‐6 and omega‐3 oxylipins as potential markers of cardiometabolic risk in young adults

L Jurado‐Fasoli, X Di, I Kohler, FJ Osuna‐Prieto… - …, 2022 - Wiley Online Library
Abstract Objective Omega‐6 and omega‐3 oxylipins are known to play a role in
inflammation and cardiometabolic diseases in preclinical models. The associations between …

No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

B Martinez-Tellez, G Sanchez-Delgado… - Nature …, 2022 - nature.com
Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue
(WAT) browning in murine models. Whether this is true in humans, however, has remained …

The evolutionary significance of human brown adipose tissue: Integrating the timescales of adaptation

SB Levy, WR Leonard - Evolutionary Anthropology: Issues …, 2022 - Wiley Online Library
While human adaptability is regarded as a classical topic in anthropology, recent work
provides new insight into metabolic adaptations to cold climates and the role of phenotypic …

Infrared thermography for estimating supraclavicular skin temperature and BAT activity in humans: a systematic review

D Jimenez‐Pavon, J Corral‐Perez… - …, 2019 - Wiley Online Library
Objective Brown adipose tissue (BAT) is a thermogenic tissue with potential as a therapeutic
target in the treatment of obesity and related metabolic disorders. The most used technique …

Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts

L Jurado-Fasoli, G Sanchez-Delgado, JMA Alcantara… - …, 2024 - thelancet.com
Background There is a subset of individuals with overweight/obesity characterized by a
lower risk of cardiometabolic complications, the so-called metabolically healthy …