[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …
org) is an open‐access database resource that houses manually curated protein and …
[PDF][PDF] CRISPR-based genome editing through the lens of DNA repair
Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results
TA Yap, E Fontana, EK Lee, DR Spigel, M Højgaard… - Nature medicine, 2023 - nature.com
Predictive biomarkers of response are essential to effectively guide targeted cancer
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …
Untangling the roles of TOP2A and TOP2B in transcription and cancer
L Uusküla-Reimand, MD Wilson - Science advances, 2022 - science.org
Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
Transcription-coupled nucleotide excision repair and the transcriptional response to UV-induced DNA damage
N Nieto Moreno, AM Olthof… - Annual Review of …, 2023 - annualreviews.org
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
Leveraging the replication stress response to optimize cancer therapy
E Cybulla, A Vindigni - Nature Reviews Cancer, 2023 - nature.com
High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …
Mechanisms of vertebrate DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
[HTML][HTML] Mapping the genetic landscape of DNA double-strand break repair
Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for
maintaining genomic integrity. To systematically map these pathways, we developed a high …
maintaining genomic integrity. To systematically map these pathways, we developed a high …