Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures involved in
fundamental biological processes. As G4s are promising anticancer targets, in past decades …

Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a
deficiency in repairing DNA crosslinks, which are known to perturb several cellular …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …

ADP-ribose (ADPr) readers are essential components of ADP-ribosylation signaling, which
regulates genome maintenance and immunity. The identification and discrimination …

The ATR kinase, which coordinates cellular responses to DNA replication stress, is also
essential for the proliferation of normal unstressed cells. Although its role in the replication …

HECT ubiquitin ligases play essential roles in metazoan development and physiology. The
HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of …

Combinations of ataxia telangiectasia-and Rad3-related kinase inhibitors (ATRis) and poly
(ADP-ribose) polymerase inhibitors (PARPis) synergistically kill tumor cells through …

DNA damage-activated signaling pathways are critical for coordinating multiple cellular
processes, which must be tightly regulated to maintain genome stability. To provide a …

Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is
thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to …

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Its
diagnosis at advanced stage compounded with its excessive genomic and cellular …