Recent preclinical and clinical research has led to exciting advances related to high-grade
serous ovarian cancer, from examining its cellular origins to gaining insight into DNA …

CRISPR-Cas technology has transformed functional genomics, yet understanding of how
individual exons differentially shape cellular phenotypes remains limited. Here, we …

The post-translational modification of proteins by SUMO is crucial for cellular viability and
mammalian development in part due to the contribution of SUMOylation to genome …

The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is
crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells …

The metabolic plasticity of mitochondria ensures cell development, differentiation, and
survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress …

All cells contain specialized signaling pathways that enable adaptation to specific molecular
stressors. Yet, whether these pathways are centrally regulated in complex physiological …

A critical determinant of DNA repair pathway choice is REV7, an adaptor that binds to
various DNA repair proteins through its C-terminal seatbelt domain. The REV7 seatbelt …

Chromatin organization must be maintained during cell proliferation to preserve cellular
identity and genome integrity. However, DNA replication results in transient displacement of …

To maintain genome integrity, cells must accurately duplicate their genome and repair DNA
lesions when they occur. To uncover genes that suppress DNA damage in human cells, we …

Biallelic germ line excision repair cross-complementing 6 like 2 (ERCC6L2) variants
strongly predispose to bone marrow failure (BMF) and myeloid malignancies, characterized …