Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers. It has a
high mortality rate and requires novel effective drugs and therapeutic approaches. Juniperus …

Simple Summary Prognosis for patients with oesophageal cancer is poor, because of its
aggressive nature and the lack of targeted therapies. Advances in cancer biology and …

Esophageal cancer comprises two different histological forms–squamous cell carcinoma
(SCC) and adenocarcinoma (AC). While the incidence of AC has increased steeply in …

Gastric cancer is one of the most common types of cancer in the world, usually diagnosed at
an advanced stage. Despite the advances in specific anticancer agents' development, the …

Background Gastric and esophageal adenocarcinomas are major global cancer burdens.
These cancer forms are characterized by a poor prognosis and a modest response to chemo …

Purpose Angiogenesis is a promising therapeutic target to inhibit tumor growth. This review
summarizes data from clinical trials of anti-angiogenic agents in gastric cancer. Design A …

Esophageal cancer is one of the most aggressive malignancies of the upper aerodigestive
tract. Despite advances in surgical techniques and multi-modality therapies, the 5-year …

In the West in particular, the vast majority of gastric cancer (GC) patients present with
advanced-stage disease. Although combination chemotherapy is still the most important …

Metastatic lymph node density (ND) has been reproducibly proven to be a prognostic factor
in gastric cancer. The molecular mechanisms that underlie this aggressiveness are …

Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification
of the protein. The human genome encodes approximately 538 kinases. Kinases play a role …