Estimates indicate that the global cancer burden may be ever-increasing. Gastric cancer is
one of the major cancer forms. Despite its declining incidence, the high mortality of gastric …

Since its discovery several decades ago, the Epidermal Growth Factor Receptor (EGFR) has
become one of the most extensively studies receptor tyrosine kinases. However, despite …

In the West in particular, the vast majority of gastric cancer (GC) patients present with
advanced-stage disease. Although combination chemotherapy is still the most important …

Gastric cancer, including cancer of the gastroesophageal junction (GEJ), is a global health
problem with approximately 1 million people diagnosed every year worldwide. 1 In the …

Gastrointestinal carcinomas account for more cancerrelated deaths than those of any other
organ system. Recent discoveries have uncovered key genetic, epigenetic, and …

This chapter summarizes recent progress in the treatment of patients with advanced
adenocarcinoma of the esophageal and gastroesophageal junction, with a focus on the …

Patients with esophageal cancer have a very poor survival. Hence, there is a demand for
new treatment options. Interfering with hyaluronan (HA) synthesis is a promising approach …

The incidence of carcinoma of the oesophagus in Slovenia is small and has not changed in
years. The prognosis of patients with metastatic carcinoma of the oesophagus is poor, with …

Trastuzumab has been the first targeted agent approved by the FDA for the first line
treatment of ERBB2-positive advanced gastric cancer patients. This anti-HER2 drug …

The prevalence of autism has increased in an exponential way in the past few years. Many
monogenetic mutations as well as copy number variants and single nucleotide …