[HTML][HTML] Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma
M Vahabi, B Dehni, I Antomás, E Giovannetti… - Cancer and Metastasis …, 2023 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor
prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to …
prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to …
[PDF][PDF] Hepatic kinome atlas: An in‐depth identification of kinase pathways in liver fibrosis of humans and rodents
Abstract Background and Aims Resolution of pathways that converge to induce deleterious
effects in hepatic diseases, such as in the later stages, have potential antifibrotic effects that …
effects in hepatic diseases, such as in the later stages, have potential antifibrotic effects that …
[HTML][HTML] B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin
C Zhou, X Zhu, N Liu, X Dong, X Zhang… - Signal transduction and …, 2023 - nature.com
Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the
malignancy of pancreatic cancer. Family with sequence similarity 83 member A (FAM83A) …
malignancy of pancreatic cancer. Family with sequence similarity 83 member A (FAM83A) …
[HTML][HTML] Kinome array profiling of patient-derived pancreatic ductal adenocarcinoma identifies differentially active protein tyrosine kinases
Pancreatic cancer remains one of the most difficult malignancies to treat. Minimal
improvements in patient outcomes and persistently abysmal patient survival rates …
improvements in patient outcomes and persistently abysmal patient survival rates …
[HTML][HTML] A panel of seven immune-related genes can serve as a good predictive biomarker for cervical squamous cell carcinoma
J Dai, Y Pan, Y Chen, S Yao - Frontiers in Genetics, 2022 - frontiersin.org
Objective: Cervical cancer is one of the most common gynecological malignancies. The
interaction between tumor microenvironment and immune infiltration is closely related to the …
interaction between tumor microenvironment and immune infiltration is closely related to the …
HCK is a potential prognostic biomarker that correlates with immune cell infiltration in acute myeloid leukemia
F Cheng, Q Li, J Wang, L Wang, W Li… - Disease Markers, 2022 - Wiley Online Library
Background. The tumor microenvironment (TME) plays a significant role in the progression
and prognosis of acute myeloid leukemia (AML). This study is aimed at exploring TME …
and prognosis of acute myeloid leukemia (AML). This study is aimed at exploring TME …
Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia
Standard treatments have shown dismal activity against pancreatic cancer (PC), due in part
to the development of a dense stroma (desmoplasia). This perspective discusses the …
to the development of a dense stroma (desmoplasia). This perspective discusses the …
Graph Attention Networks for Drug Combination Discovery: Targeting Pancreatic Cancer Genes with RAIN Protocol
Background: Malignant neoplasm of the pancreas (MNP), a highly lethal illness with bleak
outlook and few therapeutic avenues, entails numerous cellular transformations. These …
outlook and few therapeutic avenues, entails numerous cellular transformations. These …
[HTML][HTML] Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation
J Jiao, L Ruan, C Cheng, F Wang, P Yang, Z Chen - Molecular Medicine, 2023 - Springer
Background Protein kinases play a pivotal role in the malignant evolution of pancreatic
cancer (PC) through mediating phosphorylation. Many kinase inhibitors have been …
cancer (PC) through mediating phosphorylation. Many kinase inhibitors have been …
[HTML][HTML] Recent advances in kinase drug discovery part I: the editors' take
This special issue on Advances in Kinase Drug Discovery provides a selection of research
articles and topical reviews covering all aspects of drug discovery targeting the …
articles and topical reviews covering all aspects of drug discovery targeting the …