Although cardiac tumor formation is rare, accumulating evidence suggests that the two
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

Peripheral artery disease (PAD) is a vascular disorder caused by occlusive atherosclerosis,
which commonly impairs blood flow to the lower extremities. The prevalence of PAD is …

Cardiac lymphangiogenesis plays an important physiological role in the regulation of
interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive …

Adenoviral vectors are commonly used in clinical gene therapy. Apart from oncolytic
adenoviruses, vector replication is highly undesired as it may pose a safety risk for the …

Sialidosis (Mucolipidosis I) is a glycoprotein storage disease, clinically characterized by a
spectrum of systemic and neurological phenotypes. The primary cause of the disease is …

Background: Cardiovascular diseases are the leading cause of death globally. In spite of the
availability of improved treatments, there is still a large group of chronic ischemia patients …

Gene therapy is a technique that rectifies defective or abnormal genes by introducing
exogenous genes into target cells to cure the disease. Although gene therapy has gained …

Exosomes paracrine-secreted by EPC (EPC-EXO) may exert strong pro-angiogenic effects,
which offers a potential means to treat ischemic diseases. However, the mechanism of EPC …

Cardiovascular diseases (CVDs) are responsible for enormous socio-economic impact and
the highest mortality globally. The standard of care for CVDs, which includes medications …