The implicit paradigm that has governed the study and clinical management of preterm
labour is that term and preterm parturition are the same processes, except for the gestational …

Mechanisms underlying the initiation of parturition remain unclear. Throughout most of
pregnancy, uterine quiescence is maintained by elevated progesterone acting through …

Progesterone is a critical regulator of normal female reproductive function, with diverse
tissue-specific effects in the human. The effects of progesterone are mediated by its nuclear …

Progesterone acting via the progesterone receptor (PR) plays a critical role in maintaining
uterine quiescence during pregnancy. In the present study, we tested the hypothesis that the …

Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with
endometriosis has been reported. Aromatase induction may be mediated by increased …

Infertility and reproductive-associated disease are global problems in the world today
affecting millions of women. A successful pregnancy requires a healthy uterus ready to …

The uterus and breasts are hormone-responsive tissues. Progesterone and estradiol
regulate gonadotropin secretion, prepare the endometrium for implantation, maintain …

Progesterone is an ovarian steroid hormone that is essential for normal breast development
during puberty and in preparation for lactation and breastfeeding. The actions of …

The steroid hormones progesterone (P4) and estradiol-17β (E2), produced by the placenta
in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy …

Context: Custom-compounded bioidentical hormone therapy (HT) has become widely used
in current endocrine practice, which has led to unnecessary risks with treatment. Objective …