Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …

Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …

Abstract Purpose of Review To highlight the added benefits of approved and upcoming,
centrally-acting, anti-obesity drugs, focusing not only on the most common metabolic and …

ABSTRACT Introduction Recently, the European Medicines Agency (EMA) received reports
of suicidal thoughts and self-injury associated with glucagon-like peptide-1 receptor …

Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …

There is significant evidence linking a 'reward deficiency syndrome'(RDS), comprising
decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like …

Different types of rewards such as food and money can similarly drive our behavior owing to
shared brain processes encoding their subjective value. However, while the value of money …

The relationship between hunger and subsequent feeding has undoubtedly provided strong
selective pressures that underpin motivation, learning and memory processes. Together …

The vagus nerve plays a vital role in the regulation of food intake and vagal afferent signals
may help regulate food cue reactivity by providing negative homeostatic feedback. Despite …