Context It is increasingly evident that non–protein-coding regions of the genome can give
rise to transcripts that form functional layers of the cancer genome. One of most abundant …

Simple Summary Genome-wide association studies have identified a vast number of cancer
risk-associated loci harboring numerous single nucleotide polymorphisms that regulate …

Transposable elements hold regulatory functions that impact cell fate determination by
controlling gene expression. However, little is known about the transcriptional machinery …

Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Understanding the mechanisms underlying tumorigenesis requires comprehensive
annotation of the cancer genome. The majority of the human genome consists of noncoding …

Cancer is driven by both germline and somatic genetic changes. Efforts have been devoted
to characterizing essential genetic variations in cancer initiation and development. Most …

Bone metastasis is associated with cancer‐related death in patients with prostate cancer
(PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa …

Over the last decade, more than 10 independent SNPs have been discovered to be
associated with the risk of renal cell carcinoma among different populations. However, the …

Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory
elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we …