Long non-coding RNAs (lncRNAs) play key roles in colorectal carcinogenesis. Here, we
aimed to identify the risk SNP-induced lncRNAs and to investigate their roles in colorectal …

Long noncoding RNAs (lncRNAs) have been indicated as important regulators in various
human cancers. However, the overall biological roles and clinical significance of most …

A key challenge in the management of localized prostate cancer is the identification of men
with a high likelihood of progression to an advanced, incurable stage. Patients who harbour …

Gene expression is controlled by the involvement of gene-proximal (promoters) and distal
(enhancers) regulatory elements. Our previous results demonstrated that a subset of gene …

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants
and their underlying molecular mechanisms remain largely unknown. Through systematic …

The genetic basis of disease has largely focused on coding regions. However, it has
become clear that a large proportion of the noncoding genome is functional and harbors …

Genome-wide association studies (GWASs) have identified more than 200 prostate cancer
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …

Abstract The N6-methyladenosine (m6A) modification plays important regulatory roles in
gene expression, cancer occurrence and metastasis. Herein, we aimed to explore the …

In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested
phenotype for years. Upon injury, a rapid phenotypic switch facilitates proliferation to restore …

Long noncoding RNAs (lncRNAs) have crucial functions in the tumorigenesis and
metastasis of cancers. N6-methyladenosine (m6A) modification of RNA is an important …