[HTML][HTML] Second-generation antipsychotics and dysregulation of glucose metabolism: beyond weight gain
D Grajales, V Ferreira, ÁM Valverde - Cells, 2019 - mdpi.com
Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia
because of their high clinical efficacy. However, SGA treatment is associated with severe …
because of their high clinical efficacy. However, SGA treatment is associated with severe …
Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications
Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …
Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms …
A de Bartolomeis, L Vellucci, A Barone… - Pharmacology & …, 2022 - Elsevier
Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
Pharmacological management of glucose dysregulation in patients treated with second-generation antipsychotics
Fasting hyperglycemia, impaired glucose tolerance, prediabetes, and diabetes are
frequently present in patients treated with second-generation antipsychotics (SGAPs) for …
frequently present in patients treated with second-generation antipsychotics (SGAPs) for …
[HTML][HTML] A focused review of the metabolic side-effects of clozapine
JWY Yuen, DD Kim, RM Procyshyn… - Frontiers in …, 2021 - frontiersin.org
The second generation antipsychotic drug clozapine represents the most effective
pharmacotherapy for treatment-resistant psychosis. It is also associated with low rates of …
pharmacotherapy for treatment-resistant psychosis. It is also associated with low rates of …
[HTML][HTML] Endocrine disruption and obesity: A current review on environmental obesogens
Obesity represents an important public health concern because it substantially increases the
risk of multiple chronic diseases and thereby contributing to a decline in both quality of life …
risk of multiple chronic diseases and thereby contributing to a decline in both quality of life …
Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes
FJ Ascaso, R Rodriguez-Jimenez, L Cabezón… - Psychiatry …, 2015 - Elsevier
Optical coherence tomography (OCT) has been recently used to investigate
neuropsychiatric disorders. We aimed to study retinal OCT measures of patients with …
neuropsychiatric disorders. We aimed to study retinal OCT measures of patients with …
Antipsychotics-induced metabolic alterations: focus on adipose tissue and molecular mechanisms
P Gonçalves, JR Araújo, F Martel - European Neuropsychopharmacology, 2015 - Elsevier
The use of antipsychotic drugs for the treatment of mood disorders and psychosis has
increased dramatically over the last decade. Despite its consumption being associated with …
increased dramatically over the last decade. Despite its consumption being associated with …
[HTML][HTML] Molecular mechanisms of antipsychotic drug-induced diabetes
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As
mental disorders are chronic diseases, these drugs are often used over a life-time. However …
mental disorders are chronic diseases, these drugs are often used over a life-time. However …
[HTML][HTML] C-reactive protein as a peripheral biomarker in schizophrenia. An updated systematic review
Objectives: The objective of this systematic review was to synthetize the published data on
the relationships between elevated blood C-reactive protein (CRP) levels and schizophrenia …
the relationships between elevated blood C-reactive protein (CRP) levels and schizophrenia …