Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous
metabolism of keratinocytes. The development of psoriasis is closely related to abnormal …

Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M
and K. They were first discovered in the 1980s within cytotoxic granules released during NK …

Objective This study investigated CX3CR1 expression in human peripheral blood T
lymphocytes and their subsets, exploring changes in SLE patients and its diagnostic …

Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical
manifestations. Although parasites influence disease severity, cytolytic CD8 T cell responses …

Gastrointestinal (GI) tumors pose a significant global health burden, necessitating the
exploration of novel therapeutic approaches. Plasmacytoid dendritic cells (pDCs) play a …

Alopecia areata (AA) is an autoimmune-mediated disorder in which the proximal hair follicle
(HF) attack results in non-scarring partial to total scalp or body hair loss. Despite the growing …

Objective To gain insights into how proteases signal to connective tissues cells in the
periodontium. Background The connective tissue degradation observed in periodontitis is …

Background Type 1 diabetes mellitus (T1DM) may be associated with various autoimmune
diseases, but the causal relationship between T1DM and autoimmune skin diseases is not …

Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical
manifestations. Although parasites influence disease severity, cytolytic CD8 T cell responses …

Unlike in infection and cancer, T cell exhaustion in autoimmune disease has not been
clearly defined. Here we set out to understand inhibitory protein (PD-1, Tim3, CTLA4, Lag3) …