Malaria biology and disease pathogenesis: insights for new treatments
LH Miller, HC Ackerman, X Su, TE Wellems - Nature medicine, 2013 - nature.com
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …
claims the lives of nearly a million children each year in Africa alone and is a top public …
Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
The African genome variation project shapes medical genetics in Africa
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …
detailed characterization of African genetic diversity is needed. The African Genome …
Diversity and inclusion in genomic research: why the uneven progress?
AR Bentley, S Callier, CN Rotimi - Journal of community genetics, 2017 - Springer
Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …
understanding of human history, biology, and health disparities, in addition to discoveries of …
Genotype imputation with thousands of genomes
Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …
resolution of genetic association studies. Imputation methods work by using haplotype …
Genomewide association studies and assessment of the risk of disease
TA Manolio - New England journal of medicine, 2010 - Mass Medical Soc
Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
C Crosnier, LY Bustamante, SJ Bartholdson, AK Bei… - Nature, 2011 - nature.com
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria.
Invasion requires a series of extracellular recognition events between erythrocyte receptors …
Invasion requires a series of extracellular recognition events between erythrocyte receptors …
World distribution, population genetics, and health burden of the hemoglobinopathies
TN Williams, DJ Weatherall - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Although information about the precise world distribution and frequency of the inherited
hemoglobin disorders is still limited, there is no doubt that they are going to pose an …
hemoglobin disorders is still limited, there is no doubt that they are going to pose an …
Human genetic susceptibility to infectious disease
SJ Chapman, AVS Hill - Nature Reviews Genetics, 2012 - nature.com
Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …
Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities
TB Mersha, T Abebe - Human genomics, 2015 - Springer
This review explores the limitations of self-reported race, ethnicity, and genetic ancestry in
biomedical research. Various terminologies are used to classify human differences in …
biomedical research. Various terminologies are used to classify human differences in …