Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays …

Microglia, often described as the brain-resident macrophages, play crucial roles in central
nervous system development, maintenance, plasticity, and adaptation to the environment …

The recently developed new genome-editing technologies, such as the CRISPR/Cas
system, have opened the door for generating genetically modified nonhuman primate (NHP) …

Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically
characterized by cardinal motor deficits including bradykinesia, tremor, rigidity and postural …

Background: Levodopa remains the gold‐standard treatment for PD. However, it becomes
less effective as the disease progresses and produces debilitating side effects, such as …

Introduction Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease. PD patients exhibit a classic spectrum of motor …

Rhesus macaque (RM, Macaca mulatta), as an important model animal, commonly suffers
from chronic diarrheal disease, challenging the breeding of RMs. Gut microbiomes play key …

Parkinson's disease (PD) is a progressive neurological disorder characterised by aberrant
accumulation of insoluble proteins, including alpha‐synuclein, and a loss of dopaminergic …

Parkinson's disease (PD) is characterized by the presence of inflammation-mediated
dopaminergic neurodegeneration in the substantia nigra. Inflammatory mediators from …