[HTML][HTML] Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine

I Agrawal, YS Lim, SY Ng, SC Ling - Translational Neurodegeneration, 2022 - Springer
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …

[HTML][HTML] Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

CP Chang, KC Wu, CY Lin, Y Chern - Journal of Biomedical Science, 2021 - Springer
In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

[HTML][HTML] Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

YL Xiao, Y Gong, YJ Qi, ZM Shao… - Signal Transduction and …, 2024 - nature.com
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

[HTML][HTML] Mitochondria: a Promising Convergent Target for the treatment of amyotrophic lateral sclerosis

T Cunha-Oliveira, L Montezinho, RF Simões… - Cells, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study

MRJ van Mantgem, RPA van Eijk… - Journal of Neurology …, 2020 - jnnp.bmj.com
Objective To determine the prevalence and prognostic value of weight loss (WL) prior to
diagnosis in patients with amyotrophic lateral sclerosis (ALS). Methods We enrolled patients …

European Academy of Neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European Reference Network for …

P Van Damme, A Al‐Chalabi… - European journal of …, 2024 - Wiley Online Library
Background This update of the guideline on the management of amyotrophic lateral
sclerosis (ALS) was commissioned by the European Academy of Neurology (EAN) and …

[HTML][HTML] Skeletal muscle in ALS: an unappreciated therapeutic opportunity?

S Scaricamazza, I Salvatori, A Ferri, C Valle - Cells, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
selective degeneration of upper and lower motor neurons and by the progressive weakness …

[HTML][HTML] Diet, microbiota and brain health: unraveling the network intersecting metabolism and neurodegeneration

F Gentile, PE Doneddu, N Riva… - International journal of …, 2020 - mdpi.com
Increasing evidence gives support for the idea that extra-neuronal factors may affect brain
physiology and its predisposition to neurodegenerative diseases. Epidemiological and …

[HTML][HTML] Investigation of the prognostic predictive value of serum lipid profiles in amyotrophic lateral sclerosis: roles of sex and hypermetabolism

R Nakamura, M Kurihara, N Ogawa, A Kitamura… - Scientific Reports, 2022 - nature.com
The prognostic predictive value of lipid profiling in amyotrophic lateral sclerosis (ALS)
remains unclear. Here, we aimed to clarify the value of the levels of serum lipids, including …

[HTML][HTML] Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis

M Bolborea, P Vercruysse, T Daria, JC Reiners… - Acta …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is associated with impaired energy metabolism,
including weight loss and decreased appetite which are negatively correlated with survival …