Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Tapentadol is an analgesic compound that acts centrally to attenuate pain. Previous studies
have shown that tapentadol has dual mechanisms of action as a mu-opioid receptor agonist …

Persistent pain is a prevalent medical concern correlating with a hyperexcitable anterior
cingulate cortex (ACC). Its activity is modulated by inputs from several brain regions, but the …

Aims/hypothesis While the risk factors for diabetic peripheral neuropathy (DPN) are now well
recognised, the risk factors for painful DPN remain unknown. We performed analysis of the …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Neuropathic pain (NP) is a prevalent clinical problem for which satisfactory treatment options
are unavailable. Tetrandrine (TET), a bisbenzylisoquinoline alkaloid extracted from …

Abstract Background and Purpose Chronic pain is a devastating problem affecting one in
five individuals around the globe, with neuropathic pain the most debilitating and poorly …

Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an
injury or disease of the somatosensory nervous system, which induces abnormal painful …

It has long been recognized that men and women have different degrees of susceptibility to
chronic pain. Greater recognition of the sexual dimorphism in chronic pain has resulted in …

Pain assessment is a complex task largely dependent on the patient's self-report. Artificial
intelligence (AI) has emerged as a promising tool for automating and objectifying pain …