[HTML][HTML] Tumor angiogenesis and anti-angiogenic strategies for cancer treatment

RI Teleanu, C Chircov, AM Grumezescu… - Journal of clinical …, 2019 - mdpi.com
Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

[HTML][HTML] Exosomes in angiogenesis and anti-angiogenic therapy in cancers

W Olejarz, G Kubiak-Tomaszewska… - International Journal of …, 2020 - mdpi.com
Angiogenesis is the process through which new blood vessels are formed from pre-existing
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …

[HTML][HTML] Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …

Surufatinib in advanced pancreatic neuroendocrine tumours (SANET-p): a randomised, double-blind, placebo-controlled, phase 3 study

J Xu, L Shen, C Bai, W Wang, J Li, X Yu, Z Li… - The Lancet …, 2020 - thelancet.com
Background Surufatinib showed superior efficacy in extrapancreatic neuroendocrine
tumours (NETs) in the phase 3 SANET-ep study. In SANET-p, we aimed to assess the …

[HTML][HTML] Novel drugs with high efficacy against tumor angiogenesis

S Qi, S Deng, Z Lian, K Yu - International Journal of Molecular Sciences, 2022 - mdpi.com
Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

[HTML][HTML] Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

JJ Qin, XD Cheng, J Zhang, WD Zhang - Cell Communication and …, 2019 - Springer
Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis
and low rate of survival. Despite the advances in understanding this devastating disease …

[HTML][HTML] Glutamine synthetase as a therapeutic target for cancer treatment

GW Kim, DH Lee, YH Jeon, J Yoo, SY Kim… - International journal of …, 2021 - mdpi.com
The significance of glutamine in cancer metabolism has been extensively studied. Cancer
cells consume an excessive amount of glutamine to facilitate rapid proliferation. Thus …

[HTML][HTML] Autophagy: a key player in pancreatic cancer progression and a potential drug target

J Gillson, YS Abd El-Aziz, LYW Leck, PJ Jansson… - Cancers, 2022 - mdpi.com
Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …

[HTML][HTML] The state-of-the-art of phase II/III clinical trials for targeted pancreatic cancer therapies

A Garcia-Sampedro, G Gaggia, A Ney… - Journal of Clinical …, 2021 - mdpi.com
Pancreatic cancer is a devastating disease with very poor prognosis. Currently, surgery
followed by adjuvant chemotherapy represents the only curative option which, unfortunately …

[HTML][HTML] Role of Nrf2 in pancreatic cancer

M Cykowiak, V Krajka-Kuźniak - Antioxidants, 2021 - mdpi.com
Pancreatic tumors are a serious health problem with a 7% mortality rate worldwide.
Inflammatory processes and oxidative stress play important roles in the development of …