The clinical translation of stem cells and their extracellular vesicles (EVs)-based therapy for
central nervous system (CNS) diseases is booming. Nevertheless, the insufficient CNS …

Background Sleep disturbances and disorders are a common and sometimes recalcitrant
problem in persons recovering from substance use disorders (SUDs). As such, several …

N-degron pathways are a set of proteolytic systems that target the N-terminal destabilizing
residues of substrates for proteasomal degradation. Recently, the Gly/N-degron pathway …

The oxytocin (OXT) system has garnered considerable interest due to its influence on
diverse behaviours. However, scant research has considered the influence of oxytocin on …

Aims The aim of this study was to assess the efficacy of self-administered intranasal oxytocin
on alcohol dependence after detoxification. Methods In a double-blind, randomized, placebo …

Oxytocin regulates a variety of centrally-mediated functions, ranging from socio-sexual
behavior, maternal care, and affiliation to fear, stress, anxiety. In the past years, both clinical …

The initial enthusiasm towards oxytocin (OXT) as a potential treatment for alcohol use
disorder has been recently tempered by recognizing existing gaps in literature and the …

Background Improving sleep health is an important target for substance use disorder (SUD)
research. However, there is little guidance for SUD researchers regarding the use of …

Development of better treatments for alcohol use disorder (AUD) is urgently needed. One
promising opportunity for this development is the potential of targeting the oxytocin peptide …

The hypothalamic neuropeptide oxytocin (OT) is well known for its prosocial, anxiolytic, and
ameliorating effects on various psychiatric conditions, including alcohol use disorder (AUD) …