Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease,
that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively …

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Abstract Background Sec23 homolog A (SEC23A), a core component of coat protein
complex II (COPII), has been reported to be involved in several cancers. However, the role of …

The gut microbiota plays a key role in host health and disease, particularly through their
interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic …

A complex mucus network made up of large polymers of the mucin-family glycoprotein
MUC2 exists between the large intestinal microbial mass and epithelial and immune cells …

Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs
are characterized by a damaged mucus layer, which does not separate the intestinal …

Colitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges
from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic …

Intestinal epithelial cells form the largest barrier in the body, separating us from the outside
world. Here, we review recent findings that highlight the role of autophagy in the cell-intrinsic …

Heat stress (HS) occurs when the sensible temperature of animals exceeds their
thermoregulatory capacity, a condition that exerts a detrimental impact on health and growth …

Mucus secretion from colonic goblet cells is an important host defense mechanism against
the harsh lumenal environment. Yet how mucus secretion is regulated is not well …