The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Objective Little is known about the predictors of response to obesity interventions. Methods
In 450 participants with obesity, body composition, resting energy expenditure, satiety …

Peripheral mechanisms in appetite regulation include the motor functions of the stomach,
such as the rate of emptying and accommodation, which convey symptoms of satiation to the …

In recent years, the concept of food addiction has gained more and more popularity. This
approach acknowledges the apparent parallels between substance use disorders and …

Obesity results from an imbalance between energy intake and expenditure, and many
studies have aimed to determine why obese individuals continue to (over) consume food …

Hypothalamic regulations of food intake are altered during obesity. The dopaminergic
mesocorticolimbic system, responsible for the hedonic response to food intake, is also …

In the last few years, the concept of 'food addiction'has continued to gain popularity, with
human and animal studies demonstrating the differential effects of foods that are high in fat …

Objective The development of effective anti-obesity therapeutics relies heavily on the ability
to target specific brain homeostatic and hedonic mechanisms controlling body weight. To …

Neural plasticity is an intrinsic and essential characteristic of the nervous system that allows
animals “self-tuning” to adapt to their environment over their lifetime. Activity-dependent …