Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Charcot-Marie-Tooth (CMT) is the most prevalent category of inherited neuropathy. The most
common inheritance pattern is autosomal dominant, though there also are X-linked and …

Drugs that target histone deacetylase (HDAC) entered the pharmacopoeia in the 2000s.
However, some enigmatic phenotypes suggest off-target engagement. Here, we developed …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

This is a rapidly evolving field where better understanding of pathophysiology is paving the
way to develop potentially effective treatments, part of which will soon be tested in patients …

Central nervous system (CNS) neurodegenerative diseases are characterized by faulty
intracellular transport, cognition, and aggregate regulation. Traditionally, neuroprotection …

Epigenetic regulation orchestrates many cellular processes and greatly influences key
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …

Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and
muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs …

Peripheral nerve axons require a well-organized axonal microtubule network for efficient
transport to ensure the constant crosstalk between soma and synapse. Mutations in more …