Overcoming biological barriers including skin, mucosal membranes, blood brain barrier as
well as cell and nuclear membrane constitutes a key hurdle in the field of drug delivery …

Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic
modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense …

RNA is a polyribonucleic acid belonging to a special class of anionic polymers, holding a
unique property of self-assembly that is controllable in the construction of structures with …

RNA interference (RNAi) was intensively studied in the past decades due to its potential in
therapy of diseases. The target specificity and universal treatment spectrum endowed siRNA …

The polyanionic nature of oligonucleotides and their enzymatic degradation present
challenges for the use of siRNA in research and therapy; among the most notable of these is …

Taking advantage of the highly permeable vasculature and lack of lymphatic drainage in
solid tumors (EPR effect), nanosized drug delivery systems or nanomedicines have been …

Rheumatoid arthritis (RA) is a common autoimmune disease, which is characterized by
painful chronic inflammation in the joints, and novel safe and efficacious treatments are …

This study examines the antitumor potential of curcumin and C6 ceramide (C6) against
osteosarcoma (OS) cell lines when both are encapsulated in the bilayer of liposomal …

Understanding the delivery dynamics of nucleic acid nanocarriers is fundamental to improve
their design for therapeutic applications. We investigated the carrier structure–function …

Some genes expressed in stem cells interrupt and/or enhance differentiation. Therefore, the
aim of this study was to inhibit the expression of unnecessary genes and enhance the …