Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review
The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
[HTML][HTML] Exploring Antimicrobial Features for New Imidazo [4, 5-b] pyridine Derivatives Based on Experimental and Theoretical Study
M Hjouji, AM Almehdi, H Elmsellem, Y Seqqat… - Molecules, 2023 - mdpi.com
5-bromopyridine-2, 3-diamine reacted with benzaldehyde to afford the corresponding 6-
Bromo-2-phenyl-3H-imidazo [4, 5-b] pyridine (1). The reaction of the latter compound (1) …
Bromo-2-phenyl-3H-imidazo [4, 5-b] pyridine (1). The reaction of the latter compound (1) …
Synthesis of N-acylated pyrazolines: Spectroscopic, crystallographic, Hirshfeld Surface, lead sensing and theoretical studies
Abstract N-Acylated-2-pyrazolines (NA2Pyr) were synthesized from chalcone and hydrazine
hydrate under one pot cyclocondensation in the presence of propionic acid and …
hydrate under one pot cyclocondensation in the presence of propionic acid and …
[HTML][HTML] Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their …
FF Alblewi, MH Alsehli, ZM Hritani… - International Journal of …, 2023 - mdpi.com
In this study, novel selective antitumor compounds were synthesized based on their
fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular …
fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular …
Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic …
Microbiological DNA gyrase is recognized as an exceptional microbial target for the
innovative development of low-resistant and more effective antimicrobial drugs. Hence, we …
innovative development of low-resistant and more effective antimicrobial drugs. Hence, we …
[HTML][HTML] Targeted potent antimicrobial and antitumor oxygen-heterocyclic-based pyran analogues: synthesis and computational studies
The process of creating a series of 3-amino-1-aryl-8-methoxy-1 H-benzo [f] chromene-2-
carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate …
carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate …
Prominent antidiabetic and anticancer investigation of Scrophularia deserti extract: Integration of experimental and computational approaches
Diabetes mellitus (DM) is a group of syndromes and complications characterized by
hyperglycemia, metabolic disorders in lipids, carbohydrates, and proteins. It causes an …
hyperglycemia, metabolic disorders in lipids, carbohydrates, and proteins. It causes an …
Cu (II) salen complex grafted onto KCC-1 as a convenient multifunctional heterogeneous catalyst for the preparation of 4H-benzochromenes
K Ghabdian, A Motavalizadehkakhky, R Zhiani… - Research on Chemical …, 2024 - Springer
A complex of Cu (II) salen was grafted on the surface of KCC-1 nanoparticles using 3-
chloropropyltrimethoxysilan as a linker to obtain Cu (II) salen@ KCC-1. SEM and TEM …
chloropropyltrimethoxysilan as a linker to obtain Cu (II) salen@ KCC-1. SEM and TEM …
Thermal kinetics and molecular modeling studies of ZnII-poly (vinyl alcohol-nicotinic acid) complexes
Complexes of poly (vinyl alcohol-nicotinic acid) with Zn II (Zn II/PVA-NA) were synthesized
by incipient wetness impregnation. The successful synthesis of PVA-NA and Zn II/PVA-NA …
by incipient wetness impregnation. The successful synthesis of PVA-NA and Zn II/PVA-NA …
[HTML][HTML] New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK …
SA Badawy, AR Hassan, RH Elkousy - RSC advances, 2023 - pubs.rsc.org
In vitro anticancer screening of Silene succulenta Forssk. aerial parts (Caryophyllaceae)
showed that the n-hexane fraction was a highly effective fraction against breast carcinoma …
showed that the n-hexane fraction was a highly effective fraction against breast carcinoma …