[HTML][HTML] Potential therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition
MHH Berg, SV Del Rincón, WH Miller - Journal for Immunotherapy …, 2022 - ncbi.nlm.nih.gov
The therapeutic benefits of immune checkpoint inhibitors (ICIs), which enable antitumor
immune responses, can be tempered by unwanted immune-related adverse events (irAEs) …
immune responses, can be tempered by unwanted immune-related adverse events (irAEs) …
Targeting Bruton's tyrosine kinase in inflammatory and autoimmune pathologies
SFH Neys, RW Hendriks, OBJ Corneth - Frontiers in cell and …, 2021 - frontiersin.org
Bruton's tyrosine kinase (BTK) was discovered due to its importance in B cell development,
and it has a critical role in signal transduction downstream of the B cell receptor (BCR) …
and it has a critical role in signal transduction downstream of the B cell receptor (BCR) …
[HTML][HTML] Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes
X Hong, Y Zhou, Z Zhu, Y Li, Z Li, Y Zhang, X Hu… - Environment …, 2023 - Elsevier
Abstract Background Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor,
has been extensively demonstrated to be associated with metabolic disorders, including …
has been extensively demonstrated to be associated with metabolic disorders, including …
Mitochondrial reactive oxygen species are essential for the development of psoriatic inflammation
S Mizuguchi, K Gotoh, Y Nakashima… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease that affects
approximately 2–3% of the population worldwide. Although there is increasing evidence …
approximately 2–3% of the population worldwide. Although there is increasing evidence …
Pyruvate kinase M2 mediates glycolysis contributes to psoriasis by promoting keratinocyte proliferation
Y Liu, M Xu, X Dai, L Yan, L Li, R Zhu, L Ren… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2
isoform of pyruvate kinase (PKM2) was reported to have an important role in cell …
isoform of pyruvate kinase (PKM2) was reported to have an important role in cell …
Multifaceted immunomodulatory effects of the BTK inhibitors ibrutinib and acalabrutinib on different immune cell subsets–beyond B lymphocytes
S Zhu, S Gokhale, J Jung, E Spirollari, J Tsai… - Frontiers in cell and …, 2021 - frontiersin.org
The clinical success of the two BTK inhibitors, ibrutinib and acalabrutinib, represents a major
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …
Bruton's tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice
Sepsis is a life-threatening condition which affects multiple organs including the kidney.
Sepsis-induced acute kidney injury (AKI) is a major health burden throughout the globe …
Sepsis-induced acute kidney injury (AKI) is a major health burden throughout the globe …
Pharmacological inhibition of STAT3 by stattic ameliorates clinical symptoms and reduces autoinflammation in myeloid, lymphoid, and neuronal tissue compartments …
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that leads to
demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid …
demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid …
Liposome mediated topical delivery of Ibrutinib and Curcumin as a synergistic approach to combat imiquimod induced psoriasis
Psoriasis is an autoimmune dermal disorder characterized by the emergence of red patches,
scaling and does not have any proficient therapeutic option. The study involves the …
scaling and does not have any proficient therapeutic option. The study involves the …
The extracellular vesicles from the commensal Staphylococcus epidermidis ATCC12228 strain regulate skin inflammation in the imiquimod-induced psoriasis murine …
F Gómez-Chávez, C Cedillo-Peláez… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are evaginations of the cytoplasmic membrane, containing
nucleic acids, proteins, lipids, enzymes, and toxins. EVs participate in various bacterial …
nucleic acids, proteins, lipids, enzymes, and toxins. EVs participate in various bacterial …