MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant
activation of signaling pathways driving cellular proliferation, survival, and therapeutic …

Over the last decade, the use of targeted therapies has immensely increased in the
treatment of cancer. However, treatment for endometrial carcinomas (ECs) has lagged …

Phosphoprotein phosphatases are of growing interest in the pathophysiology of many
diseases and are often the neglected partner of protein kinases. One family member, PP2A …

Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and
plays emerging roles in cancer. Activating transcription factor 6 (ATF 6), one of the three …

Background Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and
cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting …

Cellular processes are dictated by the active signaling of proteins relaying messages to
regulate cell proliferation, apoptosis, signal transduction and cell communications. An …

In cancer cells, tumor suppressor proteins loss-of-function are usually the result of genetic
mutations. Protein Phosphatase 2A is a tumor suppressor that inactivates several signaling …