Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced …

J Deng, W Tan, Q Luo, L Lin, L Zheng… - Frontiers in Physiology, 2021 - frontiersin.org
Background and Objective: Acute kidney injury (AKI) is a complication of sepsis. Pyroptosis
of gasdermin D (GSDMD)-mediated tubular epithelial cells (TECs) play important roles in …

[HTML][HTML] Long non-coding RNAs: potential biomarkers and targets for hepatocellular carcinoma therapy and diagnosis

D Yuan, Y Chen, X Li, J Li, Y Zhao, J Shen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. Increasing studies showed that long non-coding RNAs (lncRNAs), a novel class …

PIWIL1/piRNA-DQ593109 regulates the permeability of the blood-tumor barrier via the MEG3/miR-330-5p/RUNX3 axis

S Shen, H Yu, X Liu, Y Liu, J Zheng, P Wang… - … Therapy-Nucleic Acids, 2018 - cell.com
The blood-tumor barrier (BTB) restricts the efficient delivery of anti-glioma drugs to cranial
glioma tissues. Increased BTB permeability may allow greater delivery of the therapeutic …

LncRNAs: the art of being influential without protein

LR Gonzales, S Blom, R Henriques, CWB Bachem… - Trends in Plant …, 2024 - cell.com
The plant long noncoding (lnc) RNA field is on the brink of transitioning from large-scale
identification of lncRNAs to their functional characterization. Due to the cross-kingdom …

Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma

MJ Heo, J Yun, SG Kim - Archives of pharmacal research, 2019 - Springer
Hepatocellular carcinoma (HCC) is a tumor with poor prognosis and frequently aggressive.
The development of HCC is associated with fibrosis and cirrhosis, which mainly results from …

lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11

Z Liu, JY Chen, Y Zhong, L Xie, JS Li - Brazilian Journal of Medical …, 2019 - SciELO Brasil
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor
suppressor, is critical for the carcinogenesis and progression of different cancers, including …

HCC-Related lncRNAs: roles and mechanisms

M Shah, D Sarkar - International journal of molecular sciences, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) presents a significant global health threat, particularly in
regions endemic to hepatitis B and C viruses, and because of the ongoing pandemic of …

LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR‐320/S100A10 axis

JT Zhao, BJ Chi, Y Sun, N Chi, X Zhang… - Cell biochemistry …, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Multiple long non‐coding
RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumour suppressors …

Interaction of long noncoding RNA MEG3 with miRNAs: A reciprocal regulation

MT Moradi, H Fallahi, Z Rahimi - Journal of cellular …, 2019 - Wiley Online Library
The competitive endogenous RNA (ceRNA) hypothesis suggests that a long noncoding
RNA (lncRNA) can function as sinks for pools of microRNAs (miRNAs); thereby, in the …

[HTML][HTML] HOXA-AS2 promotes proliferation and induces epithelial-mesenchymal transition via the miR-520c-3p/GPC3 axis in hepatocellular carcinoma

Y Zhang, J Xu, S Zhang, J An, J Zhang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Previous studies have demonstrated that long non-coding RNAs
(lncRNAs) may play critical roles in cancer biology, including Hepatocellular carcinoma …