[HTML][HTML] Gut microbiota metabolites in major depressive disorder—Deep insights into their pathophysiological role and potential translational applications

MA Ortega, MA Alvarez-Mon, C García-Montero… - Metabolites, 2022 - mdpi.com
The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

[HTML][HTML] Effect of exercise on brain health: the potential role of lactate as a myokine

T Hashimoto, H Tsukamoto, S Ando, S Ogoh - Metabolites, 2021 - mdpi.com
It has been well established in epidemiological studies and randomized controlled trials that
habitual exercise is beneficial for brain health, such as cognition and mental health …

[HTML][HTML] Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

[HTML][HTML] Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression

K Zhang, F Wang, M Zhai, M He, Y Hu, L Feng, Y Li… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Depression is a mental disorder that poses a serious threat to human health.
Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of …

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

X Dong, Q Zhang, X Yu, D Wang, J Ma, J Ma… - Nature …, 2022 - nature.com
Proper neural progenitor behavior in conjunction with orderly vasculature formation is
fundamental to the development of the neocortex. However, the mechanisms coordinating …

[HTML][HTML] AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models

X Li, T Teng, W Yan, L Fan, X Liu, G Clarke… - Translational …, 2023 - nature.com
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The
pathogenesis of MDD remained unclear, and it may be associated with exposure to different …

[HTML][HTML] Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

PB Souza, L de Araujo Borba… - International journal of …, 2023 - mdpi.com
Major depressive disorder (MDD) has a high prevalence and is a major contributor to the
global burden of disease. This psychiatric disorder results from a complex interaction …

[HTML][HTML] Continuous theta-burst stimulation enhances and sustains neurogenesis following ischemic stroke

X Zong, J Gu, S Zhou, D Ding, Y Hu, L Tucker… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Previous work has indicated that continuous theta-burst stimulation (cTBS), a
modality of transcranial magnetic stimulation (TMS), may provide neuroprotection and …

Akebia saponin D acts via the PPAR‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to …

J Zhang, Q Liu, D Su, L Li, C Xiao, H He… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Using drugs to modulate microglial function may be an effective way to treat
disorders, such as depression, that involve impaired neurogenesis. Akebia saponin D (ASD) …

Lactate improves long-term cognitive impairment induced by repeated neonatal sevoflurane exposures through SIRT1-mediated regulation of adult hippocampal …

LL Qiu, XX Tan, JJ Yang, MH Ji, H Zhang, C Zhao… - Molecular …, 2023 - Springer
Repeated neonatal exposures to sevoflurane induce long-term cognitive impairment that
has been reported to have sex-dependent differences. Exercise promotes learning and …